Therefore, if the enhanced production of iNOS in the gastric mucosa is maintained after vaccination, it may be an unwanted side effect that can augment the severity of H. pylori-induced inflammation and malignancy, unless sterile immunity is achieved.
Microorganisms express molecules that can activate the immune system and therefore can augment the severity of disease (Cooke et al., 1998).
We also report that the metastatic breast cancer cells augment the severity of arthritis resulting in a vicious cycle that increases both bone destruction and metastasis.
Patients with septic shock, in particular, would benefit because antibiotics are known to promote the liberation of pro-inflammatory cell components and thus augment the severity of septic shock [ 37, 38].
Thus, the Yaa genetic modifier is called an accelerator because by itself it does not initiate disease but rather it augments the severity in lupus-prone genetic backgrounds (Izui et al., 1988).
Thus, we hypothesize that the pro-inflammatory microenvironment in the arthritic bone may boost the recruitment of the 4T1 cells and that the 4T1 cells in turn augments the severity of arthritis; thus creating a highly conducive microenvironment for the 4T1 tumors to further proliferate.
Importantly, the SKG + zymosan mice bearing the 4T1 tumors had a two-fold increase in joint swelling compared with the same mice bearing the TUBO tumors or no tumors, suggesting that the metastatic 4T1 breast cancer cells may have the potential to augment the severity of arthritis.
These comorbid conditions may augment the perceived severity of migrainous symptoms and/or pose additional challenges for effective patient management.
In recent years, this risk has been augmented by the severity of the HIV epidemic in LMICs.
Yet their own efforts contributed to the suddenness and severity of the crash, thereby augmenting the evictions and redundancies it precipitated.
