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Augmenting the induction of apoptosis or enhancing the cryosensitization of tumor cells by coupling cryoablation with specific chemotherapy effectively increases the efficiency of this therapeutic treatment.
However, consistent with increased DAF-16 activity in prdx-2-mutant animals augmenting the induction of dauer at higher temperatures (Ailion & Thomas, 2000), there appeared to be a small increase in the proportion of prdx-2-mutant animals that formed dauer at 27 °C.
Therefore, since glioma cells surviving under sublethal temperature would subsequently undergo intrinsic or extrinsic apoptosis, augmenting the induction of apoptosis or enhancing the cryosensitization of tumor cells by coupling cryoablation with specific chemotherapy might effectively increase the efficiency of this therapeutic treatment.
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Finally, we found that LRRK2 also augmented the induction of inflammatory cytokines during ER stress.
Herein we have also found that change in regulatory cytokine profile of TAMs was able to redirect the T helper function, reprogram Treg population and augment the induction of protective immune response in EAC/Dox bearing mice.
Overexpression experiments further revealed that HDAC2 could augment the induction of iNOS promoter activity [ 137].
Transgenic expression of IL-28A was recently shown to augment the induction of Th1 responses and the severity of ConA-induced liver injury (Siebler et al, 2007).
The involvement of RUNX3 appears particularly important during inflammation and infection, as it strongly augmented the induction of IL23A by TNF-α/NF-κB and H. pylori.
Conversely, reduction of endogenous miR-155 levels with a partially complementary antisense sequence augmented the induction of antigen-specific T cells.
In vitro, PCT augmented the induction of inducible nitric oxide synthase in cultured smooth muscle cells preincubated with proinflammatory stimuli [ 40].
Intravenous administration of Fungizone, an amphotericin B preparation complexed with deoxycholate, augmented the induction of endogenous TNF in response to a second stimulus with intravenous doses of FK23 (heat-killed Enterococcus faecalis).
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