In conclusion, the results demonstrate that SATB2 facilitates the differentiation of iPSCs towards osteoblast-lineage cells by repressing HoxA2 and augmenting the functions of the osteoblast determinants Runx2, BSP and OCN.
The expectation was that this combination of biodegradable scaffolds and cells would yield functional tissue constructs, which, upon implantation by surgeons, would eventually fulfill the aim of replacing or augmenting the functions of the damaged or diseased tissues in situ.
Unlike first-generation left ventricular assist devices, which were developed in the 1970s and were designed to totally capture the cardiac output, the Jarvik 2000 is designed to normalize the cardiac output by augmenting the function of the chronically failed heart for extended periods.
For example, augmenting the function of the astrocyte glutamate transporter EAAT2 with parawexin 1, a molecule isolated from spider venom, protects retinal neurons from ischemic degeneration by enhancing glutamate uptake and reducing excitotoxicity [ 70].
Further, it is not clear whether increasing the mass and augmenting the function of major skeletal muscle groups in Asian Indians could have a better effect on insulin sensitivity compared with its effect in other ethnic groups.
Including nuts in your salads and desserts augments the functioning of the digestive system as well as immune system and improves the skin quality to prevent cancer.
Genomic, proteomic, and functional analyses have uncovered unanticipated cellulosomal proteins that augment the function of the native and designer cellulosomes.
Our studies demonstrate that the transplantation of autologous mitochondria, isolated from the patient's own body, and then directly injected into the myocardial during early reperfusion augment the function of native mitochondria damaged during ischemia and enhances myocardial post-ischemic functional recovery and cellular viability.
However, some progress is being made toward achieving targeted lung repair and the creation of a biohybrid device that can augment the function of damaged lung.
Since SIRPα is a cellular ligand of CD47, which can augment the functions of integrins of the β1, β2 and β3 families via initiating heterotrimeric Gi protein signaling [49], thus modulating a range of cell activities including cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.
