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Unlike first-generation left ventricular assist devices, which were developed in the 1970s and were designed to totally capture the cardiac output, the Jarvik 2000 is designed to normalize the cardiac output by augmenting the function of the chronically failed heart for extended periods.
For example, augmenting the function of the astrocyte glutamate transporter EAAT2 with parawexin 1, a molecule isolated from spider venom, protects retinal neurons from ischemic degeneration by enhancing glutamate uptake and reducing excitotoxicity [ 70].
Further, it is not clear whether increasing the mass and augmenting the function of major skeletal muscle groups in Asian Indians could have a better effect on insulin sensitivity compared with its effect in other ethnic groups.
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This is an example of what Markoff refers to as a "human out-of-the-loop" model, in which software replaces human agency entirely, as opposed to augmenting the functioning of humans "in-the-loop," as with things like assisted parking or G.P.S. technology.
The expectation was that this combination of biodegradable scaffolds and cells would yield functional tissue constructs, which, upon implantation by surgeons, would eventually fulfill the aim of replacing or augmenting the functions of the damaged or diseased tissues in situ.
In conclusion, the results demonstrate that SATB2 facilitates the differentiation of iPSCs towards osteoblast-lineage cells by repressing HoxA2 and augmenting the functions of the osteoblast determinants Runx2, BSP and OCN.
Genomic, proteomic, and functional analyses have uncovered unanticipated cellulosomal proteins that augment the function of the native and designer cellulosomes.
Our studies demonstrate that the transplantation of autologous mitochondria, isolated from the patient's own body, and then directly injected into the myocardial during early reperfusion augment the function of native mitochondria damaged during ischemia and enhances myocardial post-ischemic functional recovery and cellular viability.
However, some progress is being made toward achieving targeted lung repair and the creation of a biohybrid device that can augment the function of damaged lung.
Thus, determining the factors influencing T-bet and Eomes expression may provide promising therapeutic interventions to augment the function of NK cells in aging.
One intriguing possibility relevant to RA is that latent CMV infection is associated with increased differentiation of diverse T-cell specificities, suggesting that this could augment the function of autoreactive T cells in the joints of patients with RA [ 87].
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