Ketamine was also able to abolish this fear conditioning (FC+Ket vs. FC groups) response in the Nacc (p<0.0001; Fig. 6C), while showing a trend at augmenting the response of fear conditioning in the ACC (p = 0.053) and LC (p = 0.103).
Indeed, it is intriguing to hypothesize that testosterone levels may augment the response of PsA patients to biologic therapies.
In addition, anti-IGF-1R therapy was shown to augment the response of certain malignant tumors to RT in preclinical settings 18, 19.
We show that Notch signalling augments the response of neuroepithelial cells to Shh, leading to the induction of higher expression levels of the Shh target gene Ptch1 and subsequently induction of more ventral cell fates.
Here, we report a novel role for Notch in augmenting the response of neural progenitors to Shh in the chick and mouse neural tube, and provide insight into the establishment of floor plate and P3 identity.
In vitro, bryostatin 1 activates protein kinase C (PKC), induces the differentiation of a number of cancer cell lineages, exhibits anti-tumour activity and augments the response of haemopoietic cells to certain growth factors.
In addition to the presence of DAMPs, synovial fluid from patients with early OA has been shown to augment the responses of TLR2 and TLR4 in fibroblast-like synoviocytes through the provision of increased levels of the TLR accessory molecule CD14 [ 50].
To investigate this, we tested whether NMD inhibition augments the response to induction of ER stress.
Moreover, we have observed that exposing MM cells to GSK-3 inhibitors could augment the response to the cytotoxic effects of BZ, a clinically used chief therapeutic agent in MM therapy.
Interestingly, upon comparing the secretion of IL-12 from the three different knock-out conditions during vhs- infection it was apparent that the presence of TLR3 significantly augments the response to the highly stimulatory vhs- virus.
