We therefore hypothesized that an isolated increase of RR would augment the development of ventilator induced lung injury (VILI).
However, a better understanding of the inter-relationship between nonclinical and clinical predictors/measures of cardiovascular risk as well as a more integrated and predictive development strategy could dramatically augment the development of safe and effective medicines for patients in need.
These results indicate that although dynamic loading augments the development of bulk properties in these samples, possibly by overcoming some of the diffusion limitation and nutrient transport issues, the overall profile of construct properties in the axial direction remains qualitatively the same as in free-swelling culture conditions.
In murine autoimmune encephalomyelitis, blockade of the IL-1 receptor antagonist (IL-1RA) permits soluble IL-1β to bind the IL-1 receptor type 1 (IL-1R1), augmenting the development of clinical encephalomyelitis and T-cells expression of IFN-γ [23].
It is possible that altered secretory patterns associated with gastric inflammation augment the development of obesity-associated conditions.
We review the work demonstrating that gammaherpesvirus infection of Th2-biased mice leads to multi-organ fibrosis and highlight studies showing that gammaherpesviral infections of mice either pre- or post-fibrotic challenge can augment the development of fibrosis.
Cyclic stretch of alveolar epithelial cells in MV has been observed to enhance bacterial growth and bacteremia, thereby augmenting the development of sepsis and organ failure [ 6, 23, 29, 30].
Investigating strategies, involving monoclonal antibodies, combinatorial peptides, and small molecules (identified by high throughput screening) to manipulate and modulate different aspects of these pathways, would augment the development of new therapeutic options to manage IBD.
In many patients, particularly those with type 2 diabetes, the diabetes-associated clinical findings are amplified by the existence of these comorbidities, augmenting the development of left ventricular hypertrophy, increasing the susceptibility of the heart to ischemic injury, and increasing the overall likelihood of developing heart failure.
As neutrophil depletion just before infection augments the development of immunity to sand fly-transmitted infection and of a Leishmania-specific T-cell response, the capture of infected neutrophils by DCs in the skin was suggested as a key mechanism to inhibit their APC function and to delay the development of acquired resistance.
