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Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.
We downloaded DrGaP at http://code.google.com/p/drgap/ and we applied it with default settings to the lists of somatic mutations identified by muTect and VarScan2 and on the same lists augmented with the RAREVATOR somatic calls.
Private somatic CNVs occurred more frequently than private somatic mutations.
Somatic mutations identified from enrolled patients.
Detecting Somatic Mutations in Normal Cells.
We identified somatic mutations in memory-type36 CD8+ T cells.
Next, we analyzed somatic mutations in 29 SCCs.
Pathway alterations include homozygous deletions, focal amplifications and somatic mutations.
Extended Data Fig. 3 Somatic mutations in solitary sampling.
Four hundred twenty-six genes had recurrent somatic mutations.
Somatic mutations were not evenly scattered across the genome.
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