These reports were the first to demonstrate that a history of EBV infection can augment responsiveness to particular alloantigens.
Our results also suggest that therapeutic strategies that increase TP73 expression may be useful to augment responsiveness of medulloblastomas to chemotherapy.
In the present study, AT2R deficiency augmented pressor responsiveness to AngII in adult female mice.
Recently attempts of ovarian androgen priming have been developed on the basis that temporary exposure of follicles to increased levels of androgens may augment their responsiveness to FSH.
CSB and XPA may represent rational targets to augment cisplatin responsiveness of tumours, independent of MMR capacity and p53.
Nef does not enhance NF-κB activation on its own, but it augments the responsiveness to other stimuli, most likely because a certain state of cellular activation is needed to allow productive virus infection.
One such factor is TNF, a cytokine that enhances OC formation by upregulating the stromal cell production of RANKL and M-CSF [ 12] and by augmenting the responsiveness of OC precursors to RANKL [ 13].
In addition, in accord with the current thinking that hypoxia-induced production of VEGF mediates tumoral resistance to radiotherapy and chemotherapy (Harmey & Bouchier-Heyes 2002), the anti-VEGF activity of bevacizumab has been shown to augment the responsiveness of NSCLC tumors to radiotherapy and platinum-based chemotherapy in nude mice (Kabbinavar et al. 1995).
Moreover, a novel, promising anticancer drug, indole-3-carbinol (13C), was shown to increase the expression of the IFN-gamma receptor 1 and augmented the interferon responsiveness in breast cancer cells [ 26].
The present study shows augmented vascular α-AR responsiveness, in magnitude and in duration, in conscious type 2 diabetic and obese animals, at clinical doses of phenylephrine (32).
