Exact(6)
The KO list was then loaded into the pathway identification tool at the KOBAS web-server to identify statistically augmented pathways in the data set [ 29].
Figures 4A and B show the comparisons between the rankings and p values of the bait list and the literature augmented pathways.
In the STRING experiment, these edges are already present in cDSD, so cDSD=caDSD gives the naive way to put in these edges, whereas capDSD puts them in as augmented pathways.
The performance of other methods was not as clearly served by the augmented pathways; capDSD improved functional flow in the noisier STRING setting, but not on BioGRID.
So it remains to answer the main question of the article, whether using the augmented pathways as controlled-access highways is a better way to incorporate pathway information than just using individual edges.
Similar improvements are seen for capDSD with unweighted majority vote and functional flow on STRING, though these are not the best performing methods overall, while performance of multi-way cut degrades with augmented pathways.
Similar(53)
We present three new dissimilarity measures, which we call cDSD, caDSD or capDSD, respectively, where capDSD stands for confidence, augmented pathway diffusion state distance.
By means of two correlation analyses and two PPI analyses on fMRI data acquired during the performance of a grasping task, we confirmed our a priori hypothesis that augmented pathway efficacy is mirrored in increases in inter-regional functional connectivity.
One study found DKK1 to be preferentially expressed in hormone receptor-negative cancers; as DKK is a Wnt target gene, however, this elevation may actually indicate augmented pathway activity [ 126].
Network analysis of biological pathways can also be a useful tool to augment pathways with knowledge from various resources.
This effect was also more obvious under 0.1% hypoxia compared with normoxia, suggesting that the cellular stress induced by both DETA/NO and hypoxia augmented this pathway of apoptosis.
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