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LTP was reduced and LTD was augmented in comparison to diploid controls in the isolated hippocampus of Ts65Dn and Ts1Cje, two DS murine models carrying a partial trisomy 16 encompassing the DYRK1A gene [38], [39], [40].
The intrinsic excitability represented by the PS amplitude was less expressed compared to the control group (Fig. 9B), but still was significantly augmented in comparison to baseline levels (ANOVA, n = 6, p<0.01).
The cerebral endothelium forms tighter junctions than other endothelia that are characterized by greater electrical resistance and contain specific proteins, including enzymes and transporters, whose expression appears to be augmented in comparison to other endothelia [4], [8] [11].
It increases if the contribution of the double activation process is augmented in comparison to the single activation process.
Immunoblot analysis revealed that when cells were incubated with 17-AAG (50 nM) in combination with NH4Cl (50 mM) for 24, the level of LC3-II was further augmented in comparison to the treatment with 17-AAG alone (Fig. 4C), pointing to an enhancement of the autophagic flux by 17-AAG [38].
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MMP 1 expression was significantly higher than in the control group but not significantly augmented in comparison with groups II and III (p = 0.025).
Maniotis's experiments reveal chromosomal discontinuity as an artifact of past experiments: chromosomes are linked by threads of DNA (chromolinkers), a characteristic they share with the ancestral, circular 'genophore', though being augmented and restructured in comparison to it.
Of interest the overexpression of GAP-43 mRNA at 7 dpi resulted in an increased immunopositivity to GAP-43 at 8 weeks: in treated animals the percentage of GAP-43 positive fibers within the cyst augmented more than twofold in comparison to controls.
Furthermore, the ERK and P38 phosphorylation were evidently augmented after Mel administration in comparison to I/R group.
Interestingly, Ca+2 release from the ER after Thapsi treatment is augmented in NE-treated cardiomyocytes in comparison to control and IGF-1-treated cardiomyocytes, further indicating that the reduction in mitochondrial Ca2+ uptake is not due to a reduction in ER Ca2+ loading (Additional file 4: Figure S4).
Voided stain on paper analysis revealed that silk augmented animals displayed similar voiding patterns in comparison to non surgical controls by 42 d of implantation.
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