No relationship was found between drug concentration and treatment response, even in augmented doses.
Adverse reactions are categorized into five types, the most important of which are type-A (augmented), dose-dependent, and type-B (bizarre), non-dose-dependent [4].
They started with 2 cycles of ifosfamide, carboplatin, etoposide (ICE) in a standard or augmented dose (aICE), followed by FDG-PET.
Traditional prescribing culture involves recognition of factors that mandate dose reduction (such as renal impairment), although optimizing drug exposure, through more frequent or augmented dosing, represents an evolving strategy.
Based on hyper-CVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) as a backbone, we designed an augmented version with intensified doses of vincristine, dexamethasone, and asparaginase (L-asparaginase in the first 62 patients and pegaspargase in the remainder) starting from course 1. Ninety patients have been enrolled, with a median age of 34 years (range, 14-70 years).
Even very low doses of LPS elicit an augmented response to subsequent endotoxin challenge with a violent immune response [ 42 ].
This observation is consistent with the findings of others that have used lower therapeutically efficacious doses [ 34, 35] and support a rationale for application of lower doses of Sunitinib to avoid augmented invasive or metastatic potential.
Indeed, inhibition of caspase-1 reduced the release of IL-1β after stimulation with high doses of ATP but it also significantly reduced the augmented pro-IL-1β production of LPS-primed BMMCs after stimulation with low doses of ATP.
The erythroid progenitor bias observed at low doses of exogenous ATRA suggests that the erythroid-specific stimulation might lead to augmented intracellular retinoids, although this is largely speculative.
