Sentence examples for augmented degradation from inspiring English sources

Our findings that a unique oncogenic βTrCP1 E3-ligase mediates augmented degradation of FOXO3 protein will significantly contribute to an understanding of the control of FOXO3 protein stability and extend the parallel mechanism of regulation between FOXO3 and p53 in cancer cells.

It will be important to understand the physiological response in detail in order to counter-act the negative effects of phosphoketolase expression in future studies, for example by studying the effect of an augmented degradation of acetate and AcP.

TS was lesser up to 70 gpl but as concentration increased from 70 to 80 gpl, TS had increased due to the increased formation of cross links and presence of β-CD CA on cotton that augmented degradation of treated cotton at the higher temperatures.

It has also been hypothesized that a diminished conversion of the precursor form of NGF (proNGF) to mature NGF, as well as augmented degradation of the mature form, could underlie the cholinergic atrophy observed in the AD brain [6].

Currently, standard APL therapy includes retinoic acid, which promotes cell growth arrest, granulocytic differentiation and apoptosis of myeloid blasts (Huang et al, 1998) that are ascribed in part to augmented degradation of PML RAR α (Ablain et al, 2013) and increased RAR α expression (Kamimura et al, 2011).

Dispersants enhance the emulsification and dissolution of oil into the water, which augments degradation and prevents slick formation, reducing the amount of oil that reaches shorelines.

Indomethacin (1 μmol/L) completely inhibited PGE2 production but augmented collagen degradation (17.9 vs 2.3 μg per gel), and this was blocked by the addition of exogenous PGE2.

Little information regarding changes in expression of the WRN gene determined by qRT-PCR analysis is available, but it is known that its levels are decreased in in vitro aged fibroblasts [ 43], sometimes by an augmented specific degradation of the WRN mRNA [ 44].

That is, appropriate exogenous supplementation or intracellular accumulation of redox mediators all could significantly increase fluxes of electron transfer to simultaneously augment reductive degradation and bioelectricity generation.

We found that TRIM32 could associate with and ubiquitinate dysbindin augmenting its degradation.

MDMX, a homolog of MDM2, binds to the N-terminal region of p53 or heterodimerizes with MDM2, via C-terminal RING domain interaction, to augment p53 degradation.