The phrase "augmented accumulation" is grammatically correct and can be used in written English in the right context.
It refers to the process of increasing or enhancing a collection or amount of something. It would typically be used in a sentence where there is a growing accumulation of something that is being amplified or expanded. Example: The augmented accumulation of wealth in the hands of the top 1% has led to growing income inequality in society.
In addition, adoptive transfer of scFv-CTL into tumor-bearing mice effectively suppressed tumor growth due to the augmented accumulation of the transferred CTL in the tumor tissue.
The new synthetic method presented permits the synthesis of biocompatible, biodegradable high molecular weight HPMA copolymer anticancer drug conjugates that possess long-circulation times and augmented accumulation in solid tumor tissue due to the enhanced permeability and retention effect.
In particular, the increased synthesis of the newly synthesized macromolecules was mainly reflected by an augmented accumulation (up to 5.9-fold).
The data, representative of three biological replicates, consistently reflects augmented accumulation of p52 protein in the costimulation regime as compared to cell treatment with LPS or αLTβR alone for 24h.
1D-western blots showed clear effects on HSP101 and sHSP CII accumulation, and lesser effects on the sHSP CI. 2D-western-blots confirmed this and the specific augmented accumulation of some sHSP forms (Additional file 2).
Whereas the cytotoxic drugs preferentially target tumour cells, TNF mainly affects the tumour associated vasculature, possibly resulting in destruction of the vessels and augmented accumulation of the drugs in the tumour tissue (Eggermont et al, 1997; de Wilt et al, 2000c; ten Hagen et al, 2000; Van Der Veen et al, 2000).
In contrast, silencing KEAP1 augmented protein accumulation of NRF2 under basal and iAs3+-exposed conditions, whereas the iAs3+-induced protein accumulation of NRF1 was attenuated in KEAP1-KD cells.
So an augmented drug accumulation can also be achieved in the IHP setting when TNF- α is coadministered.
Podocyte derived CCN2 has also recently been proposed to have a paracrine effect on mesangial cells resulting in augmented profibrotic signalling and matrix accumulation independent of active TGFβ [ 31].
Accordingly, the increased expression of PAI-1 associated with diabetes can lead to augmented proliferation, diminished apoptosis, and hence accumulation of cells consistent with restenosis after PCI.
FDR gemcitabine infusion leads to enhanced intracellular accumulation of drug and possible augmented clinical effect.
