Sentence examples for augmentation agent from inspiring English sources
The agents had to be added to an existing antidepressant regime with the aim of achieving an improved clinical response to an ongoing antidepressant treatment (augmentation) or an earlier onset of effect when starting antidepressant and augmentation agent simultaneously (acceleration).
Yet, there remains a subset of patients who do not respond to ECT or for whom clinically adequate seizures cannot be elicited, for whom ketamine has emerged as a putative augmentation agent.
Unlike most studies which have included only patients with bipolar I, this study evaluated triiodothyronine (T3) as an augmentation agent for treatment-resistant depression in patients with bipolar II and bipolar disorder NOS.
However, more clinical trial data with adequately-powered, well-designed and advanced methodology will be mandatory to conclude whether ALC as a monotherapy or augmentation agent may be efficacious and clinically beneficial for depression.
There is only one small double-blind randomised controlled study of aripiprazole as an augmentation agent in bipolar disorder.
Even though AAPs will continue to have an important role in bipolar disorders, either in combination or as an augmentation agent, the conduct of rigorous studies may be hampered by the complex study designs and large samples required, with potentially untenable financial implications.
Osteopromotive matrices are frequently employed for the local delivery and controlled release of these augmentation agents.
Based on a systematic review of the literature, including meta-analyses, randomized controlled trials (RCTs), non-randomized comparative studies and case studies, off-label augmentation agents (administered in addition to an antidepressant, without FDA approval for treatment of MDD) were identified and evaluated regarding their efficacy using levels of evidence.
There is a need for further studies of AAP as combination or augmentation agents as they are more broadly being used in bipolar disorders.
A recent systematic review and network meta-analysis of the comparative efficacy, acceptability, and tolerability of augmentation agents in treatment-resistant depression showed that quetiapine, aripiprazole, thyroid hormone and lithium were significantly more effective but less tolerable than placebo (Zhou et al. 2015).
Hyaluronic acid fillers have become popular soft tissue filler augmentation agents over the past several years.
