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As hoped, this compound augmented the potency of antibiotics in mice infected with this pathogen.Eventually, bacteria would evolve around such gimmicks, just as they evolved around antibiotics.
A medicinal chemist tinkers the drug design parameters to augment the potency, selectivity, and duration of the drug's action and to reduce the toxicity of the drug.
The DNA damaging moiety augmented the potency in BRCA2 deficient cells by 2 20 fold.
Therefore, we next set out to determine if CD19L sTRAIL can augment the anti-leukemic potency of TBI against BPL cells in vivo.
We next set out to determine if C61-LNP can augment the anti-leukemic potency of TBI against human BPL cells in vivo using our NOD/SCID mouse xenograft model of relapsed BPL.
The purpose of the present study was to examine the ability of CD19L sTRAIL, a potent and selective inducer of pro-apoptotic TRAIL signaling in CD19-positive BPL cells, to augment the anti-leukemic potency of low dose TBI in NS mouse xenograft models and CD22ΔE12xBCR double-transgenic (Tg) mouse models of radiation-resistant BPL.
Augmenting antitumor immunity is a promising way to enhance the potency of oncolytic adenoviral therapy.
The most potent compounds retained similar activity in the PAK wild type strain and the potency of these small molecules was augmented in the pump mutant mexAB-oprM (Table 6).
Surrealist touches augment the atmosphere of nightmare.
A number of acquired conditions augment the risk of thrombosis.
In addition, the potency of the DC-based vaccine was synergistically augmented when combined with anti-CAF therapy, contributing to effective suppression of tumor growth and decreased levels of immunosuppressive cytokines in tumor tissues.
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