Since SIRPα is a cellular ligand of CD47, which can augment the functions of integrins of the β1, β2 and β3 families via initiating heterotrimeric Gi protein signaling [49], thus modulating a range of cell activities including cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.
I have used a small questionnaire to obtain a 'snapshot' of breast screening units who use radiographer advanced practitioners, what they do, whether they replace or just augment the functions of a consultant radiologist, and the opinions of the radiologists working alongside them.
Genomic, proteomic, and functional analyses have uncovered unanticipated cellulosomal proteins that augment the function of the native and designer cellulosomes.
Our studies demonstrate that the transplantation of autologous mitochondria, isolated from the patient's own body, and then directly injected into the myocardial during early reperfusion augment the function of native mitochondria damaged during ischemia and enhances myocardial post-ischemic functional recovery and cellular viability.
However, some progress is being made toward achieving targeted lung repair and the creation of a biohybrid device that can augment the function of damaged lung.
Thus, determining the factors influencing T-bet and Eomes expression may provide promising therapeutic interventions to augment the function of NK cells in aging.
One intriguing possibility relevant to RA is that latent CMV infection is associated with increased differentiation of diverse T-cell specificities, suggesting that this could augment the function of autoreactive T cells in the joints of patients with RA [ 87].
For apoptosis, serine proteases have been found to complement or augment the function of caspases, e.g. granzyme B can stimulate apoptosis by cleavage of several procaspases, the pro-apoptotic protein Bid, or inhibitor of caspase-activated DNAse (ICAD) in cytotoxic T lymphocytes and natural killer cells [ 22].
In conclusion, the results demonstrate that SATB2 facilitates the differentiation of iPSCs towards osteoblast-lineage cells by repressing HoxA2 and augmenting the functions of the osteoblast determinants Runx2, BSP and OCN.
The expectation was that this combination of biodegradable scaffolds and cells would yield functional tissue constructs, which, upon implantation by surgeons, would eventually fulfill the aim of replacing or augmenting the functions of the damaged or diseased tissues in situ.
This is an example of what Markoff refers to as a "human out-of-the-loop" model, in which software replaces human agency entirely, as opposed to augmenting the functioning of humans "in-the-loop," as with things like assisted parking or G.P.S. technology.
