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Thus, by inhibiting Tregs and promoting conventional T cells, human IL-18 may have potential to restore immunocompetence in cancer patients, and thereby augment the effects of cytotoxic and biologic therapies, in order to provoke and maintain an effective anti-tumor immune response.
Moreover, the ability of ORM-10921 to augment the effects of haloperidol on the above parameters was also investigated.
The hope is that it may one day be possible to diagnose some brain diseases and mental health problems by analysing gut bacteria, and to treat them – or at least augment the effects of drug treatments – with specific bacteria.
The review finds that eating more protein, well past the amounts currently recommended, can significantly augment the effects of lifting weights, especially for people past the age of 40.
"By administering a medicine many of us take routinely, we could potentially augment the effects of PD-1 blockade, which is showing remarkable outcomes in cancer trials," said Kaech.
In principle, then, selective inhibitors of this GAP function would have potential as therapeutic agents, as they could be used to augment the effects of endogenous or exogenous GPCR agonists.
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All of the trials cited above demonstrated that CBT is effective, and can augment the effect of medication alone.
Treatment involves the removal of the thymus gland (which may produce the antibody) and medications that augment the effect of acetylcholine and suppress the immune system.
One possible advantage of aggressive tumour resection is a rapid reduction in oncological burden which may augment the effect of adjuvant chemotherapy.
Investigate the use of ovarian hormones to augment the effect of antidepressants in menopausal women.
Inhibitors targeting these microbial GGTs may thus complement or augment the effect of currently available antibiotics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com