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Thus the addition of a second, overlapping PAM2 site acts to augment the affinity of the eRF3-PABPC1 interaction without changing the stoichiometry of the interaction.
Hsp90ΔATP sustained EphA2-AKT complexes during challenge with NPGA (Figure 3A), and elicited a modest increase in their association, indicating that eHsp90 expression influences the magnitude of downstream signaling and augment the affinity of EphA2 for its binding partners.
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Importantly, in addition to K36me3 bound by the ZMYND11 PWWP domain, the H3.3-specific S31 (replaced by alanine in other H3 histones) also contributes to this interaction by being lodged into the bromo-ZnF-PWWP 'valley', greatly augmenting the affinity between the two proteins.
In order to elucidate the functional importance, Gb3Cer/CD77 fatty acid hydroxylation augments the binding affinity of Stx [57], rendering hydroxylated Gb3Cer/CD77 a highly efficient target for oncological purposes.
Taken together, these results indicate that TD-1 potently augments the oxygen affinity of hemoglobin in blood.
DOI: http://dx.doi.org/10.7554/eLife.09832.010 Taken together, these findings support the model that a major role for the helicase domain is augmenting the DNA affinity of Dna2.
Binding between the protein avidin and the vitamin biotin was used as an extrinsic, high affinity receptor-ligand system to augment the intrinsic integrin-dependent cellular adhesion mechanism.
GKAs increase the affinity of recombinant GK for glucose by as much as 10-fold and may also augment the Vmax moderately, perhaps as much as twofold.
The current study examined whether the combined introduction of high-affinity avidin-biotin bonds and fibronectin-integrin bonds (i.e., dual ligand treatment) would further augment the adhesion of flow-preconditioned endothelial cells to model substrates via contributions to the actin cytoskeleton and the formation of focal contacts.
Surrealist touches augment the atmosphere of nightmare.
Singing and costumed actors augment the readings.
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