Deficiency in p38α in IECs augmented sensitivity to colitis-associated colon cancer due to enhanced infiltration of inflammatory cells and increased apoptosis of IECs followed by compensatory hyperproliferation.
Oxytocin (OXT) acts through its specific receptor (OXTR) and increased density of OXTR and/or augmented sensitivity to OXT were postulated as prerequisites of normal onset of labor.
Increased density of OXTR and/or augmented sensitivity to OXT were postulated as prerequisites of effective parturition with normal induction of uterine contractions [ 22, 25].
Residual oil fly ash, a combustion PM rich in bioavailable metal, was evaluated in a rat model of cardiopulmonary disease (pulmonary vasculitis/hypertension) to ascertain whether the disease state augmented sensitivity to that PM.
We predict that the loss of EZH2 silencing on SEMA3A augments sensitivity to both chemo- and radiotherapy, and thus may contribute to therapy-related AML pathogenesis.
The taxotere sensitivity in HAG/src3-1 cells was reversed, if not completely, by herbimycin A, a specific inhibitor of Src family protein tyrosine kinase, indicating that Src protein tyrosine kinase augments sensitivity to taxotere.
A transient androgenic environment due to relatively short half-life (∼45 h) seems to augment follicular sensitivity to FSH.
Oncogenic addiction of activated NF-κB could be inhibited with the use of helenalin, and as such could favorably be used in a therapeutic setting to augment tumor sensitivity to conventional chemotherapeutic drugs.
Over expression of miR-181a in mature mouse T cells can augment the sensitivity to peptide antigens, while suppressing miR-181a expression can reduce sensitivity and impair both positive and negative selection [ 13].
While probabilistic extensions to sequence alignment, such as profiles and Hidden Markov Models (HMMs), can capture position-specific variation in multiple alignments, and typically demonstrate significantly augmented sensitivity, all alignment methods remain prone to similar limitations.
