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Immunohistochemical analyses of tumor specimens showed that pretreatment with systemic bevacizumab markedly increased LPAM-DNA adduct formation.Systemic treatment with bevacizumab before regional chemotherapy increases delivery of LPAM to tumor cells and represents a novel way to augment response to regional therapy for advanced extremity melanoma.
In addition, clinical observations from patients treated with recombinant IFNα for control of hepatitis C infection or malignancy indicate that in some individuals, possibly determined by their harboring genetic susceptibility factors that augment response to interferon, autoantibodies characteristic of SLE can develop [ 10, 11].
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We assessed the ability of 2 helper antigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment responses to a self-antigen (lymphoma-associated T-cell receptor) encoded by a separate plasmid after codelivery into skin by gene gun.
Q115E-substituted HLA-A2 was able to augment responses to agonist and weak agonist ligands but did not turn an antagonist ligand into an agonist (Fig. 7 and data not shown).
Given that lenalidomide has also been demonstrated to augment responses to pneumococcal vaccination through its immunomodulatory effects, a combination approach using Id vaccination alongside immunomodulatory agents is attractive [ 45].
Dermal fibroblasts from patients with SSc have an augmented response to IFN with regard to TLR3 expression.
Pdcl cKO mice also showed enhanced forelimb grips strength and augmented response to acoustic startle, suggesting further deficits in processing sensorimotor stimuli.
In MetS mice, small mesenteric arteries had an augmented response to the vasoconstrictor norepinephrine, demonstrated by measurement of sensitivity (control: logEC50 −6.170 vs. MetS: logEC50 −6.664, P < 0.001).
41 In plasmacytoid dendritic cells, LL-37 strongly augments responses to host and bacterial DNA, and this activity may contribute to the pathology of psoriasis.
Furthermore, Lbp [ 42] and Ly86 [ 43], which in conjunction with Cd14 augment responses to lipopolysaccharide (LPS), were also upregulated.
Among strategies to augment response with non-ADTs, adjunctive second-generation antipsychotics are supported by the strongest evidence [ 1].
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