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IL-18 could augment proliferation of T cells and cytotoxicity of NK cells.

For example, local and systemic injections of ASCs were shown to induce homing of such cells to existent tumors and augment proliferation of tumor cells in mice [ 37].

This is consistent with previous findings that IL-21 can augment proliferation of CD8+ T cells driven by TCR-stimulation or by IL-15 or IL-7 [ 35, 50].

It is also possible that ARA itself augments proliferation of neural progenitor cells.

Moreover, we show for the first time that CSE modulates cDC-mediated of T cells and specifically augments proliferation of CD8+T cells and inhibits proliferation of CD4+T cells in MLR.

Consistent with this stimulatory effect, osteoclasts augmented proliferation of IL-2-stimulated γδ T cells and also supported the survival of unstimulated γδ and CD4+ T cells, although these effects required co-culture with osteoclasts.

Inducible costimulator (ICOS) is highly expressed on memory CD4 T cells and has been shown to augment proliferation and survival of activated CD4 T cells.

In accord with this hypothesis, recombinant IL-27 can augment proliferation and secretion of IFN-γ by naïve CD4+ T cells [ 3, 39, 40] and when combined with IL-12, can synergize to induce IFN-γ production by human NK cells (Fig. 2) [ 3].