The KO list was then loaded into the pathway identification tool at the KOBAS web-server to identify statistically augmented pathways in the data set [ 29].
Figures 4A and B show the comparisons between the rankings and p values of the bait list and the literature augmented pathways.
In the STRING experiment, these edges are already present in cDSD, so cDSD=caDSD gives the naive way to put in these edges, whereas capDSD puts them in as augmented pathways.
We present three new dissimilarity measures, which we call cDSD, caDSD or capDSD, respectively, where capDSD stands for confidence, augmented pathway diffusion state distance.
By means of two correlation analyses and two PPI analyses on fMRI data acquired during the performance of a grasping task, we confirmed our a priori hypothesis that augmented pathway efficacy is mirrored in increases in inter-regional functional connectivity.
One study found DKK1 to be preferentially expressed in hormone receptor-negative cancers; as DKK is a Wnt target gene, however, this elevation may actually indicate augmented pathway activity [ 126].
While MITA/STING plays a critical role in the cellular response to many forms of cytosolic DNA, it appears to largely augment signaling pathways involving RIG-I and MAVS [19], [21].
These findings suggest that METH preconditioning protects against striatal DA depletion, in part, by suppressing injurious mechanisms while also augmenting neuroprotective pathways in the nigrostriatal dopaminergic pathway.
This suggests that PIK3CA mutations can further augment PI3K pathway activation mediated by other oncogenes such as ERBB2 (HER2) [ 10- 14].
This effect was also more obvious under 0.1% hypoxia compared with normoxia, suggesting that the cellular stress induced by both DETA/NO and hypoxia augmented this pathway of apoptosis.
