Whereas protecting the heart from harmful doxorubicin effects, lovastatin augmented its anticancer efficacy in a mouse xenograft model with human sarcoma cells.
Its efficacy may be further improved in the presence of other antioxidants – specifically vitamins A, C, and E. These compounds, all of which are commonly found in standard multivitamin tablets, have shown to augment the efficacy of magnesium and its ability to protect against hearing loss.
The bioactivity of Ex-4 was shown as its efficacy to augment several fold the glucose-induced insulin secretion in islets of Langerhans isolated from adult non-diabetic rats (results not shown).
9, 10 However, since ∼30 40% of patients do not respond to initial pharmacologic SE treatments, 6, 7 there remains an unmet need for efficacious treatments that can augment LZP efficacy, preferably without the risk of respiratory compromise.
While yoga therapy is not a cure, it can improve the quality of life, and may augment the efficacy of clinical treatment.
Furthermore, antibodies have been armed with cytokines, chemotherapeutic agents, toxins, and radionuclides to augment their efficacy as tumor cytotoxic agents.
To directly address this need, we propose the addition of the immunostimulatory heat shock proteins (HSPs) to active immunotherapeutic strategies to augment their efficacy.
This chapter outlines the challenges associated with effective drug and gene delivery to tumors, and strategic approaches to augment the efficacy of anticancer agents by utilizing multifunctional nanosystems.
This interaction might restrict or augment CRAds efficacy depending on the tumor type.
To our knowledge, this is the first report that long-term weakening of feedforward connections can augment the efficacy of Schaffer collateral-mediated glutamatergic transmission (see Figure S3 for model).
