Sentence examples for augment expression from inspiring English sources

The ability of MARs to protect transgenes against transcriptional silencing effects has been used to augment expression of heterologous genes.

Thus, promoter trap represents an effective strategy for identifying endogenous regulatory regions that can potentially be incorporated into expression vectors to augment expression of recombinant biopharmaceuticals.

The findings support a model where inflammatory cytokines intersect with cholesterol levels to augment expression of a module of inflammatory response factors including CX3CL1 and GM-CSF, and statins inhibit their induction.

Thus we can now ablate or augment expression of a engineered protein in the heart and are able to effectively remodel the cardiac protein profile and study the consequences of a single genetic manipulation at the molecular, biochemical, cytological and physiologic levels.

Specifically, reactive oxygen species (ROS) impair vascular relaxation and promote apoptosis of endothelial cells, augment expression of adhesion molecules and also lead to the proliferation, hypertrophy and migration of smooth muscle cells, which contribute to development of hypertension and atherosclerosis [2].

IL-10 has been previously shown to suppress pathological retinal angiogenesis [46] and reduce retinal inflammation [47] in murine models and it is possible that epoetin delta could augment expression of this cytokine in the retina, as has been shown for other EPO-treatment of other ischaemic tissues [48].

To increase the supply of 2,3-oxidosqualene, we augmented expression of the ERG1 gene, which is responsible for 2,3-oxidosqualene synthesis.

The findings suggest that intra-arterial delivery of angiotensin II with adenovirus augments expression and thus may improve gene therapy efficacy and that SSTR2-based reporter imaging is useful in comparing methods for enhancing gene expression in vivo.

We proposed that a possible mechanism of the MHC class-I up-regulation could be augmented expression and/or the activation of the APM components.

Such changes are consistent with the observation that in squamous cell carcinoma (head and neck, and lung) and inverted papilloma augmented expression of Dsg3 has been reported [13] [15], [17], [58].

For both the lung and blood, co-delivery of GM-CSF DNA with the HA DNA vaccine augmented expression of the predominant cytokine (TNF-α in the lung, IFN-γ in the blood) in the CD4+ T cell response.