CO augmented expansion of CD133+ progenitors in secondary myelopoietic organs and early differentiation of myeloid cells.
One unanswered question is whether anthracycline-based treatments can induce new tumor antigen-specific T-cells (de novo immunity) or, alternatively, augment the expansion or functional activity of preexisting tumor-reactive T-cells.
Adjuvant IL-7 potentiates the efficacy of adoptive CD4+ T-cell transfer by augmenting the expansion and persistence of polyfunctional CD4+ effector cells.
Compared to resting conditions, exercise augmented the expansion of VSTs in the placebo and bisoprolol trials (38.2% and 57.9% increases), but not in the nadolol trial (3.3% decrease).
Mutation 'X' augments clonal expansion of the HSC, that is, the leukaemia-initiating cell (LIC), whereas mutation 'Y' does not.
Though MiHA-specific CD8+ T cells could be expanded by control DCs, the use of PD-L silenced DCs strongly augmented the expansion of MiHA-specific CD8+ T cells within 2 weeks of culture (Fig. 1e).
Either by using blocking antibodies against PD-1 or PD-L1 [ 10] or by silencing the inhibitory ligands PD-L1 and PD-L2 on DCs, which results in more stimulatory DCs, we augmented the expansion of MiHA-specific CD8+ T cells of allo-SCT patients in vitro.
The aim of this study was to determine if a single exercise bout would augment the ex vivo expansion and function of γ−δ T-cells using a clinical grade protocol designed to preferentially expand the Vdelta2 subtype.
In contrast, IL-7 treatment of aged mice did not augment thymopoiesis, nor induce expansion of splenic T cells.
Therefore, we believe that PD-L silenced DCs are a safer way to interfere with the PD-1/PD-L pathway in the allo-SCT setting, and thereby potently augment the activation and expansion of MiHA-specific CD8+ T cells.
