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We hypothesized that ventilatory mechanics improvements from tiotropium would permit enhanced ability to train muscles of ambulation and therefore augment exercise tolerance benefits of PR.
Available evidence suggests that tempo-pace synchronous music can reduce exercise-perceived exertion, increase exercise endurance, augment exercise intensity and extend the duration of exercise [19,21,26,27,31-33].
The performance characteristics of the ventilator including trigger sensitivity, pressurisation rate and maximum flow capacity are important issues to be considered when using NIV to augment exercise as supporting ventilation in this context may be more demanding than during sleep.
The studies that included exercise conditioning confirmed its beneficial effects, but GH did not augment exercise effects and there was no clear improvement in strength or aerobic capacity with GH alone.
If a more robust evidence base for the effectiveness of NIV to augment exercise in AECOPD is established then the case for its use could be made to patients more strongly, which may increase compliance beyond the levels observed in the present study.
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Elevated cortisol concentrations have been reported as a primary hormonal factor augmenting exercise adaptations from high-intensity exercise, as well as impacting rates of lipolysis [20].
It remains to be established what the best strategy for augmenting exercise in this way is and we used two approaches - maintaining a fixed workload to see if endurance time increased or increasing the workload to give a greater training stimulus.
To augment adhesion, exercise therapy should be individualized, considering patient preferences, and the strategy of the lifestyle motivators should be to change the patient's perception of exercise from a sacrifice to a pleasant experience (32, 34).
We performed a double-blind, computer-randomized placebo control crossover trial at a tertiary Australian hospital to investigate whether dietary nitrate supplementation as beetroot juice (BR) would augment submaximal exercise endurance in individuals with spirometrically confirmed stable moderate COPD.
The usual comforts are augmented by exercise bikes and comic books in the corridors.
Vitamin E deprivation augmented the exercise-induced elevation in GPX activity while inhibiting exercise-induced SOD activity, possibly through elevated oxidative stress.
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