Sentence examples for augment activation of from inspiring English sources

These data indicate that CD44-CP1 repressiof of mTOR does not require AMPK activation of the tumor suppressor function of TSC2, and that CP1 can augment activation of TSC2 beyond that achieved by AMPK activation.

In vivo administration of PPZ to tumor-bearing mice resulted in an enhanced TAM recruitment in tumor microenvironment with M1 macrophage phenotype and augmented activation of TAM to tumoricidal state along with expression of tumor cytotoxic molecules.

However, short-term treatment of Aβ (within 6 h) selectively augmented activation of the PERK pathway in neurons.

However, augmented activation of effector CD4+ T cells was accompanied by the concomitant increase in the fraction of Treg cells.

This study describes a novel H3K4 methyltransferase that augments activation of several profibrogenic genes known to be necessary for the onset and progression of fibrogenesis.

We found mechanical ventilation to cause phosphorylation of eNOS and the upstream regulator of Akt with or without hyperoxia; however, hyperoxia augmented activation of Akt/eNOS early in the course of ventilation.

Staining with antibodies against allograft inflammatory factor 1 (also known as Iba1) did not reveal augmented activation of microglia in mice injected with human brain extracts in comparison to mice injected only with PBS (Additional file 7).

Furthermore, our results revealed that this combination at the cellular level augmented activation of caspase-3 and caspase-9, but not caspase-8, suggesting involvement of an intrinsic apoptotic pathway.

In addition, it is found that TCDD augments activation of NKT cell and exacerbates immune-mediated liver injury induced by concanavalin A through a mechanism involving IFN- γ and Fas ligand (FasL) [ 98].

In summary, the data show that, under LPS stimulation, NZB/W MCs exhibited a significantly augmented activation of the TLR-4-MyD88-NF-κB signaling pathway, and its resultant significantly enhanced production of MCP-1 and of OPN, compared with the DBA/W MC controls.

If so, relief of impulsivity in ADHD patients with impaired NK1R function would need a treatment that either augments activation of these receptors or mimics the downstream response.