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The combined AUC represents a weighted average of the AUC in each study.
The area under the curve (AUC) in the splanchnic group was not significantly larger than the AUC in the non-splanchnic group (0.67 versus 0.55; P = 0.20).
In the previous pharmacologic study, the mean AUC in the responders was 3.0 (range 2.30 – 3.82 (μg h ml)−1) and the AUC in nonresponders was 2.2 (range 1.10 – 3.16 (μg h ml)−1).
The AUC in HBK001-treated groups decreased by 26.5% compared to the vehicle-treated group.
Targeting unbound MPA AUC in a patient will require therapeutic drug monitoring.
Long-term prognostic value of AUC in SPECT-MPI has not been tested in existing cohorts.
AUC in CR BNO 1055 treated animals did not differ significantly from the controls (P > 0.05).
The AUC in HBK001- and linagliptin-treated groups was decreased by 13.0% and 18.6% respectively, compared to the vehicle-treated group (Fig. 3D).
In vitro skin permeation was found to have triphasic correlation with plasma AUC in the in vivo pharmacokinetic study.
Furthermore, the pharmacokinetic experiments showed that 10d had good properties of oral bioavailability, Cmax, Tmax, T1/2 and AUC in mice, respectively.
In vitro permeation across mouse skin was found to have biphasic correlation with plasma AUC in the in vivo pharmacokinetic study.
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