Sentence examples for atypical gene expression from inspiring English sources

Epigenetic alterations, such as aberrant DNA methylation of promoter and enhancer regions, which lead to atypical gene expression, have been associated with carcinogenesis.

Moreover, lack of A2 gene up-regulation (control gene spotted in each microarray) and an atypical gene expression profile have been found.

In many labs, general attempts to identify abnormalities at a molecular level revealed atypical profiles of gene expression compared to naturally conceived animals.

As microarray studies demonstrated that these cases with atypical morphology shared a gene expression profile with BL 36, 37, cases defined as atypical BL according to the third edition of the WHO classification were then categorized as BL according to the fourth edition, suggesting that the morphological spectrum of BL is very wide 24, 35.

For cyanobacteria, the atypical dependence of TBDT gene expression on different nutrition points to a yet unknown regulatory mechanism.

Then, different transcript patterns were identified for the 273 R2R3-MYB genes (including 3R and atypical MYBs) using BRAD data, and gene expression levels were calculated in RPKM units (Additional file 8: Table S2).

We excluded 13 samples with potential sex mislabeling or technical problems: (i) we checked sex identity by XIST and Y-chromosome-linked gene expression, which revealed atypical expression (too high or too low) in ten samples (accession IDs: GSM300213, GSM300250, GSM318840, GSM300288, GSM300287, GSM300326, GSM300212, GSM300255, GSM300192, GSM300300; four females & six males).

This a priori expectation does not neglect the imbalance in gene expression that ensues from the atypical gene order, but it does assume that those imbalances can be corrected by compensatory evolution.

We revealed atypical evolution around nucleocyclic TSSs, which have higher gene expression and a clear boundary in sequence composition with potentially-nucleosome-destabilizing A/T-enrichment of upstream and nucleosome-accommodating C/G-enrichment downstream of the TSSs.

Atypical hyperplasias are characterized by genetic alterations and gene expression profiles similar to those of invasive carcinomas [ 20] and are associated with an increased risk for developing cancer [ 21].

As shown by the present work, comparison of gene expression profiles can clearly distinguish between atypical antipsychotics, opioids and psychostimulants.