In particular, brain tumors are atypical, aberrant aggregates of abnormal cells that form in the brain parenchyma of the central nervous system.
c Haematoxylin-eosin-stained histologic section (original magnification, ×200) shows the tumour with atypical large lymphoid cells aggregated focally (white small arrows).
However, in the third urine specimen (3 months after the first), aggregates of atypical cells were present, suggesting high-grade urothelial carcinoma.
Lumbar puncture was performed and CSF was analyzed showing aggregates of atypical epithelial cells, lymphocytes, cell detritus and red blood cells.
An endometrial curetting showed small fragments of tumor consisting of two components; aggregates of atypical plump mononuclear cells with hyperchromatic, pleomorphic nuclei were interspersed with numerous large multinucleated osteoclast-type giant cells, some of which had more than 30 benign-appearing nuclei.
Microscopic examination of the resected specimen revealed a tumour with a circumscribed, focally infiltrative, lobulated architecture, mildly atypical epithelioid cells arranged in loose aggregates and cords within abundant myxoid stroma and scattered blood vessels.
Nevertheless, FUS-related ALS is defined as an atypical form because TDP-43-positive aggregates are not part of the pathology; therefore, this Review will not discuss FUS-related ALS.
However, the majority of the recombinant VP1 formed atypical, small (20 nm in diameter) particles or aggregates (Fig. 2j).
Atypical interspecific interactions occurred: the crab Pisidia longimana increasingly aggregated on hermit crab shells, and a hermit crab used the emerged infaunal sea urchin Schizaster canaliferus as an elevated substrate.
For example, ALRQ ovine PrP, which is associated with classical scrapie, showed an increased propensity to acquire increased β-sheet content and to aggregate compared to ALHQ PrP, which is associated with atypical scrapie.
The atypical cells tended to form junctional sheets (Fig. 8) or irregular junctional aggregates distorting the rete ridges.
