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Annual attrition in the Tijuana police department is 6.2%, but we have conservatively powered our analysis for 10% attrition per year.
Assuming 10% attrition per year and possible missing values, at least 60 children per condition and group, or at least 120 children with birth asphyxia and 120 healthy comparison children for a total of 240, need to be enrolled and randomized to either EDI plus HSC or HSC alone to achieve the desired power.
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Due to the length of time it took to recruit patients that fulfilled all the inclusion and exclusion criteria, and being cognizant of the expiry date of the special consignment of drug, we chose to cease recruitment when we achieved a sample size sufficient for a difference to be detected in the functional aspects of the study, allowing for a 5%10%% attrition rate per year.
Using PASS 2005 with a Poisson regression model and a large, but plausible overdispersion parameter (3.0, to account for excess variability), and assuming attrition of 10% per year, we obtained a sample size target of 250 at each clinical site (750 total).
A close reading of the Fortune 500 reveals an attrition rate of 7% per year.
In fact, 46percentt of teachers quit before reaching their fifth year and the cost of that attrition is approximately $7 billion per year.
Subsequent attrition was 5 10% per year.
Assuming an attrition rate of 10%% per year, our goal is to recruit 400 children.
Medical school faculty turnover is high, now averaging 8 10percentt per year; attrition is especially high among women and minority faculty members and among clinicians [ 1, 14, 27- 29].
Average rates of attrition per 100 person years both overall and by patient sub-groups were estimated.
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