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DDR impairment together with telomere attrition can result in the accumulation of genomic rearrangements that may contribute to the increased incidence of radiation-induced carcinogenesis in the elderly.
Accumulation of DNA damage and telomere attrition can result in an increase in senescent cells in tissue and organs and can subsequently result in decreased function, providing an explanation for the lower threshold to express the clinical manifestation of heart failure.
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Intragroup comparisons over time are a key strength of longitudinal cohort studies; a major threat to the validity of results from such studies is nonresponse to follow-up surveys and/or attrition, which can result in a loss of statistical power and bias.
Non-random drop-outs from studies are inevitable, and selective attrition of subjects can result in biased (often exaggerated) estimates of drug effectiveness.
Several diverse stimuli including DNA damage, oncogene expression, and telomere attrition can lead to senescence.
Residual confounding and cohort attrition can lead to bias.
First, response attrition in longitudinal studies can result in biased or underestimated associations.
Having dropout cases without reporting can result in attrition bias.
For example, failure to report the number of dropouts and completers prevents the reader from calculating attrition rates for different experimental conditions, which can result in an overestimate of treatment effectiveness.
In addition to the expense incurred in following up and tracking participants in cohort studies, loss to follow up can result in selection bias if attrition of participants is related to both exposure and outcome.
A common approach for handling attrition is to delete observations with missing values, but this complete case analysis can result in a substantial loss of power.
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CEO of Professional Science Editing for Scientists @ prosciediting.com