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This variance could be referred to the fact that MSC show telomere attrition at high passages and this type of genotoxic stress eventually may contribute to the limited replicative life-span in vitro.
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Greater attrition at higher doses early in the study may have made it difficult to measure dose response effects.
In the largest trial of 689 participants, [ 4] the attrition was high at 47.5% relative to 40.4% in the control group RA, 1.18 (95% CI, 0.99 1.39).
Experience with the pilot study suggests that we could expect attrition at a rate as high as 40%.
However, a priori, we have decided to double the required sample size (280 patients per site or 560 in total) to account for the likelihood of high attrition at follow up.
The main stem Columbia River dams are known to impose substantial impediments to Pacific lamprey migration, as there is high attrition at Bonneville Dam and at each of the dams upstream, and tagged adults successfully passing the dams are consistently larger than those that do not (e.g., Keefer et al. 2009).
In regards to the other outcomes of myocardial infarction, CABG and PCI, 19% of trials (n = 13) were rated at high risk of attrition bias.
Four studies were at high risk of attrition bias (incomplete outcome data) as a number of cases were lost to follow-up [25, 26, 28, 29, 31].
We judged one study to be at high risk for attrition bias related to incomplete outcome data; the loss to follow-up in this study of 33%% (20 out of 60 enrolled women) is sufficiently high and thus very likely to cause substantial attrition bias [37].
Six uncontrolled before-and-after studies were considered to be at high risk of attrition bias.
A few studies, however, were at high risk of attrition bias (table 2 and table C in appendix 1) and few adjusted for confounders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com