To date, the evidence base for high-quality comparative effectiveness research on how attributes of treatment efficacy, treatment burden, and potential side effects drive patient preferences for management of type 2 diabetes has been relatively lean.
This result could not be attributed to efficacy of silencing, because si- Icer was able to fully restore the mRNA level of the two other ICER target genes, Noc2 and Rab27a.
40 Finally, second generation antidepressants and cognitive behavioral therapies did not differ significantly in terms of dropouts attributed to lack of efficacy in the main analysis (risk ratio 0.36, 0.06 to 2.21; three studies 35 37 39; I=51%).
Some reports have attributed the lack of efficacy to lower systemic exposure in the CD patient population compared with RA or PS populations after etanercept administration despite evidence that TNF-α suppression is effective for these disease states [ 12].
In fact, humanity has found only one way to deliver consistently and simultaneously the four attributes of scale, permanence, efficacy and efficiency, and it is through private enterprise.
Those developing new, often more expensive, public health interventions for use in developing countries must invest in interventions with the appropriate attributes (e.g., level of efficacy, costs, mode of delivery) to realize desired health impacts.
This lack of efficacy was attributed to the slow absorption of tonabersat, suggesting that a daily administration of higher dosages should be tested for migraine prophylaxis.
In this case the lack of efficacy was attributed to insufficient exposure and CB2R occupancy.
26 When handling a dichotomous outcome in a responder analysis, it is often considered suitable to attribute patients' withdrawal to lack of efficacy, and therefore assume treatment failure 27 34 (also referred to as non-responder imputation (NRI)).
On the basis of this analysis, the absence of any reported statistically significant effect of agricultural interventions on nutritional status found by this review, as well as by other reviews that preceded this one, cannot be attributed with certainty to lack of efficacy.
