Recently, MMPs have been the object of renewed interest due to the additional roles attributed to their functions, for example, growth factor mobilisation and the processing of surface molecules (cf. Somerville et al, 2003).
The involvement of the mid and posterior cingulate cortex can probably be attributed to their monitoring function [64].
The physical locales of these cell types are probably attributed to their effector functions during brain abscess development.
However, recent findings suggest that IAPs have a much broader spectrum of action than promoting cell survival by caspase regulation; indeed, a crucial function of some IAPs consists in the regulation of inflammatory and innate immune signaling pathways, a function attributed to their E3 Ub-ligase activities [ 28].
The conservativeness of CYP51 and CYP61 is probably attributed to their essential roles in fungi-housekeeping functions in sterol biosynthesis (Kelly et al. 2009).
The antimicrobial activity demonstrated by terpenes is attributed to their interference with the integrity and functioning of the cell membrane through induction of changes in membrane potential, loss of cytoplasmic material and inhibition of the respiratory chain [ 54, 55].
Regulatory functions can predominantly be attributed to their interactions with proteins or target mRNA transcripts [ 7, 8].
In the age-specific subanalysis, the highest infection rate was found in the children group, and in some studies, the second peak in older people was also observed, the pattern may attribute to their unmature or weak immune function.
According to this biopsychosocial framework, the meaning individuals attribute to their current body structure and functioning, activities they can or cannot engage in, and the degree to which they participate in society or are restricted from doing so reflects their HRQoL [ 26].
