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Results of pharmacodynamic studies of patients with type 1 diabetes are easier to interpret as almost all glucose lowering is attributed to the study insulin.
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This difference could be attributed to the study design.
No serious AEs were attributed to the study drug.
No serious events were directly attributed to the study medications.
No deaths were attributed to the study treatment.
Furthermore, a recent study has shown that current smokers have an increased risk for severe hypoglycemia, which the investigators attributed to the decreased insulin clearance associated with smoking (35).
Unlike glucose, fructose induced metabolic syndrome is attributed mainly to the effect of fructose on insulin receptor phosphorylation while glucose induced metabolic syndrome is attributed to the higher insulin release and development of insulin resistance [ 12, 13].
Lower entrapment efficiencies were obtained around the isoelectric point of insulin (pH 5.3 to 5.4), which may be attributed to the loss of insulin because of reduced solubility.
Given the design of the study, we are unable to differentiate whether the β-cell preservation effect was attributed to the initial insulin-based therapy that all patients received in the run-in phase or attributed to ongoing therapy received after randomization.
This suggests that differences in response to the OGTT may be attributed to the action of insulin.
This phenomenon of fast reduction of blood glucose levels was also conformed within 2 h after oral delivered aspart-insulin or insulin-loaded nanoparticles, which could be attributed to the initial release of insulin from the nanoparticles [24, 28].
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