Exact(3)
The difference in the reason tumor inhibitory effect between TOPADT and RAPADT may have been attributed to the potency of the drugs and the pattern of ER expression in PC cells.
The low amount of cytokine production without CpG was attributed to the potency of CpG, also showing that the incorporation of CpG was necessary to observe synergistic activity between TLR4, 7, and 9. Expanding our studies to a broader range of cytokines and proteins via the NanoString assay, we analyzed gene expression of BMDCs after exposure to CLI-095 or CpG-ODN2088 and Indole_Lox_CpG.
23, 25 In contrast to other alkylating agents, the impact of bendamustine on DNA damage was verified to be more extensive, long-lasting and more resistant to repair, which might be attributed to the potency and lack of complete cross-resistance that distinguishes bendamustine from other alkylators.
Similar(57)
Effective grain refinement by the Al 5Ti 1B grain refiner is directly attributed to the enhanced potency of TiB2 particles with the Al3Ti 2DC and sufficient free Ti solute in the melt after grain refiner addition to achieve the columnar-to-equiaxed transition.
Enhanced heterogeneous nucleation in Al Mg alloys can be attributed to the high potency of MgAl2O4 particles with a lattice misfit of 1.4% and the increased number density of MgAl2O4 particles due to either natural dispersion by the increased Mg content or forced dispersion through intensive melt shearing.
Because the mechanisms of action for ixabepilone and paclitaxel virtually overlap, the observed differences in efficacy (SA1N fibrosarcoma, EMT-6 mammary carcinoma, and M109 lung carcinoma models) and cytotoxic T cells (M109 lung carcinoma model) may be attributed to the inherent potency of ixabepilone in these models.
Can the differences in signalling potency be attributed to the distance or route that Ca2+ must traverse to activate CaMKII?
Inspection of the crystal structures indicates that the increased potency may be attributed to the close contacts between the TAE226 and TAF089 compounds with the DFGL motif in the activation loop of FAK.
Assuming a BLG-content of more than 90%, an at least ∼100-fold higher potency can be attributed to the high molecular weight, endotoxin-contaminated fraction.
The lack of correlation with previous studies may be attributed to the increased sensitivity of flow cytometry and the greater potency of panobinostat compared with other HDAC inhibitors.
The higher potency of the azetidine derivatives was attributed to the higher electrophilic reactivity.
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