It may be attributed to the mutations of cell morphology as well as the changes of the intracellular refractive indexes, which implies the existence of the nucleus.
Despite the major antileukaemic effect of STI571 in chronic phase CML, clinical resistance to STI571 treatment was observed in patients with advanced phase diseases and was attributed to the mutations in the ATP-binding site of the Bcr-Abl protein, which alters drug binding and thus its inhibitory effects (La Rosee et al, 2002; Roche-Lestienne et al, 2002).
Furthermore, this abnormal fibrinogen binds more albumin than does normal fibrinogen, a phenomenon attributed to the mutation of serine in Aα-532 by cysteine.
In summary, the general characteristics observed for the three mutant lines were highly similar and can be clearly attributed to the mutation in ESKIMO1.
Outside of these clones, the activity of most of the remaining constructs bearing the K637L mutation increased to approximately 30 40% of the activity level of TAp63 γ, which is an effect attributed to the mutation in the sumoylation site, as a similar increase in activity was also observed when K637L was the only mutation in TAp63 α.
bAverage survival time ± SD was calculated for To confirm that the mouse virulence differences between the plaque-purified variants could be primarily attributed to the mutation at E-156, regions that encoded the additional consensus amino acid mutations at prM-141, NS4B-245, and NS5-898 were sequenced.
Reduced fitness in the 40k strain cannot be proximately attributed to the mutS mutation, which underlies the mutator phenotype; this mutation arose ∼3000 generations into the LTEE (Sniegowski et al., 1997) and is already present in the 20k strain.
Upon the addition of PAβN, only an 83.3-, 170- and 64-fold increase in the MIC of the same antibiotics was detected when making the same comparison, suggesting that this partial increment in the resistance phenotype may be attributed to the QRDR mutations.
Additional file 2: Tables S1 and S2 show that the C10 tolerance was attributed to the site mutations (Pdr1 F815S, and Pdr3 Y276H) regardless of the PDR1 mt1 and PDR3 mt expression levels.
The decreased Ca2+ affinity of LAR-GECO1 (24 μM) compared with its progenitor, R-GECO1 (0.48 μM), is mainly attributed to the D4 mutations (V51W, F395A, V411A and L415I) as they create a new complementary 'bump-and-hole' interaction between M13 and CaM [ 12].
The lower resistance of LdT is attributed to the M204I mutation only, in comparison to the multiple LAM-induced mutations.
