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The majority of between-study variation was attributed to studies that defined cases on serology.
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Side effects attributed to study treatment were 3160%0% of total events) and occurred in 4 patients during frovatriptan and in 6 patients during almotriptan treatment (P = NS).
Side effects attributed to study treatment were 89 (56.3% of total events) and occurred in 13 patients during frovatriptan and in 15 patients during rizatriptan treatment (p = NS).
This could be attributed to study area's temperature distribution; Ibadan is within moderately hot area (24 27 °C mean annual temperature), while Zaria is within hottest area (over 27 °C mean annual temperature).
No treatment-emergent serious adverse events were reported that were attributed to study drug.
Three deaths occurred during the study: two in the CDA and one in the AL group; none were attributed to study treatment by the investigator.
Primary endpoint was ART treatment failure determined by plasma HIV RNA level, CD4+ cell count decrease, death attributed to study participation, or opportunistic infection.
No deaths were attributed to study drug.
The cause of death was myocardial infarction secondary to staphylococcal sepsis, attributed to study drug.
A fifth patient died of acute myocardial infarction, which was not attributed to study treatment.
Dose reductions were required for all grade 3 or 4 toxicities attributed to study medications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com