Sentence examples for attributed to direct effects from inspiring English sources
In models in which an anti-tumor effect for VEGFR1 blockade was detected, they were attributed to direct effects on cancer cells or by modulation of angiogenesis [20], [24], but there was no data reported on hematogenous metastasis formation.
The observed impairment of fetal growth in these studies is frequently attributed to direct effects of glucocorticoids on the fetus.
Therefore aldosterone associated end-organ damage may be attributed to direct effects of aldosterone on cardiovascular tissues.
This study tries to address whether part of the treatment benefits could be attributed to direct effects of the free drug (available in the blood compartment) on tumor vascular endothelial cells.
The anticancer activity was shown to be attributed to direct antiproliferative effect and to an indirect effect manifested by upregulation of IL-12 and NK cell activity.
A 30% decrease in the incidence of pneumococcal meningitis in the United States from 1998 1999 through 2004 2005 was attributed to direct vaccine effect and herd immunity, but the percentage of cases caused by non-PCV7 serotype strains, particularly 19A, increased (7, 8 ).
This effect may be attributed to direct saturation, as it is known that direct saturation effects may be present at low off-resonance frequencies [11].
These effects were attributed to direct degradation of tau by the aminopeptidase activity of PSA (31); however, such an exoproteolytic mechanism would be quite slow and inefficient for digesting a protein as long as tau and would generate heterogenous variants of tau of diverse lengths.
Nonadditive effects were generally attributed to direct or indirect interactions of the two residues mediated through the protein or changes in mechanism.
However, at least for the cell lines and conditions used in the present study, our findings are difficult to reconcile with the idea that these antiproliferative effects can be attributed to direct interactions with cytosolic enzymes; it appears that internalised 5 remains in the lysosomes and does not reach the cytosol.
