Third, perhaps the main defects in the Hippo signalling core can be attributed to altered post-translational modifications (PTMs) at the protein level, in which case genomic data cannot be used.
Since neither 17 β-E2 nor SCH-23390 sinfluencedly influenced behavior in locomotor activity test, the anxiolytic-like synergy observed in the BWM cannot be attributed to altered motor activity.
The slower movements of the NS group may be attributed to altered motor control due to pain, see e.g., [ 33- 35] and/or mechanical dysfunction.
These findings suggest that the different biological behaviour of the cell lines cannot be attributed to altered size and charge density of their GAG chains.
Essential revisions: 1) There are a number of cases where the phenotypes/gene expression changes attributed to altering MP and SYD/BRM could be due to very indirect effects.
However, in the absence of biopsies, we are unable to dissect fully whether the observed effects can be attributed to altered ER-expression or to spill-over effects of recent therapies.
Moreover, the antitumor effects could be attributed to altered biochemical mechanisms, including inhibitions of proliferation, induction of cell cycle arrest at various cell cycle checkpoints, and enhanced apoptosis [ 50].
Likewise, changes in gene expression observed in the Δstp1 and Δstk1 strains could also be attributed to altered HU function.
Evidence of altered pain thresholds to stimuli at distant regions away from the region of reported pain symptoms has been attributed to altered central pain processing [ 30, 31, 33, 34, 63].
GERD development can be attributed to altered gastric emptying, decreased gastric compliance resulting in increased intragastric pressure, as well as the anatomical changes in the angle of His.
