Sentence examples for attributed to a proteasome from inspiring English sources
This was attributed to a proteasome inhibitory affect of chloroquine.
It is also unclear whether this toxicity can be attributed to a host of alternative off-target effects, given the pleiotropic properties associated with proteasome inhibition.
CIITA IF3 poly-ubiquitination has been attributed to an overall decrease in CIITA activity due to degradation via the ubiquitin-proteasome pathway [ 20].
In cancer patients the mechanism for the depression in protein synthesis is not known, while the increased protein degradation has been attributed to an increased expression of the ubiquitin proteasome proteolytic pathway (Khal et al, 2005).
The first one was attributed to the proteasome after ubiquitination by Mcl-1 Ubiquitin Ligase E3 (MULE) or beta transducin-containing protein (beta-TrCP).
Because earlier studies have reported that some of the anticancer effects of thiostrepton could be attributed to its proteasome inhibitory activity, we assessed the contribution of this activity to the stemness-suppressing effects of thiostrepton by evaluating the stemness properties of HCT-15 and HT-29 cells after treatment with the proteasome inhibitors MG132 and Carfilzomib (Kyprolis).
Deletions of ubp6 with hsm3 perturb 26S proteasome assembly, which we attribute to an accumulation of ubiquitylated substrates on these assembly precursors.
Assays were carried out in the absence and presence of 2.5 mM ATP and 5.0 mM Mg2+ with the difference attributed to ATP-dependent proteasome activity.
The rapid activation may be attributed to the control of proteasome as described in the article [ 18].
Intriguingly, as knockdown of Rpt2/PSMC1 expression leads to a specific impairment of 26S proteasome activity, while activity of the 20S proteasome is unaffected, neurodegeneration can be conclusively attributed to dysfunction of the 26S proteasome [31].
Similar reductions after TG treatment had been reported recently in cultured pancreatic β cells and attributed to increased protein degradation by proteasome.
