Sentence examples for attributed to a downregulation from inspiring English sources

This transformation to a differentiated state was attributed to a downregulation of the oncogenic fusion protein Fip1-like1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA), whose mRNA translation was blocked by an induction in eIF2α phosphorylation [ 14- 16].

This reduction in SICI was attributed to a compensatory downregulation of inhibitory cortical processes that developed in response to changes in cortical excitability.

Some of the effects might be attributed to a slight pAKT and cMYC downregulation Elevated level of cMYC due to PP2A downregulation, has been shown to stimulate proliferation and suppress oncogene-induced senescence in melanocytes and melanoma cells, suggesting a role of cMYC in melanoma progression 35.

When exposed to a low-dose IFN- γ (and for a shorter incubation period), STAT1 was induced in all four cell lines, indicating that the receptor is present, and that the extent of S100A4 transcriptional downregulation could not be attributed to a general difference in IFN- γ sensitivity.

The defect is attributed to a failure in Snail upregulation and E-cadherin downregulation.

Its downregulation during differentiation has been attributed to a block in transcriptional elongation within the first intron combined with posttranscriptional modulation through the action of specific micro RNAs.

The downregulation of collagen I expression may be attributed to a collagen I saturation effect experienced by the cells through integrins on the cell surface.

The here observed delayed downregulation of DNMT mRNA and protein could also be attributed to a decreased mRNA stability as was previously demonstrated for DNMT1 and DNMT3b after treatment with Trichostatin A in Jurkat or endometrial cells [ 23, 49].

The ROS increase observed upon influenza A virus infection in our experimental system was attributed to an upregulation of NOX4 at the mRNA and protein levels, accompanied by the downregulation of NOX2 (and no change in other NOXs).

Based on these reports, we speculate that the methylations at ATBF1-A gene are also not attributed to the downregulation of ATBF1-A transcripts, though we did not performed the methylation analysis.

Weed et al (2011) demonstrated that EPA supplementation was significantly associated with an increase in lean body mass in cachectic patients, a gain that may be attributed to the downregulation of the ubiquitin proteasome pathway (Tisdale, 2009).