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Likewise, we assume that the seasonal terms (harmonics) capture weekly variations not attributable to virus activity.
All of these outbreaks were attributable to virus strains of phyloclusters 2.2, groups A and B, which originated from unknown sources but had phylogenetic links to viruses isolated during outbreaks of HPAI among wild birds at Lake Qinghai in northwestern China in 2005 44, 5 – 8 ).
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The fraction of AGI attributable to viruses in the nondisinfected drinking water of the communities was estimated using QMRA.
We estimate 6 22% of the AGI in the study communities was attributable to viruses in nondisinfected tap water.
That study, however, did not compare their metagenome reads to viromes from the same subjects, which likely would have demonstrated that a far greater proportion of their metagenomes were attributable to viruses.
This suggests that the WNV epizootic observed in Israel between 1997 and 2000 may be attributable to viruses that were circulating in eastern Europe or elsewhere in the Near East since 1996.
There are many factors that may have affected this pattern; for example, hospitalizations for pneumonia and influenza attributable to viruses other than influenza, and the rate of testing by age group may have had an effect.
The mean or median of the frequency distribution of the incidence rate difference was divided by the mean or median of the total incidence to yield the fraction of AGI attributable to viruses in nondisinfected tap water [ IT – IB) ÷ IT] (Greenland et al. 2008).
Restricting the QMRA to period 1 and using the NoV-GI model for period 1, all ages [see Supplemental Material, Table S3 (http://dx.doi.org/10.1289/ehp.1104499)], the fractions of AGI in the communities attributable to viruses in nondisinfected tap water estimated using the means and medians of the frequency distributions were 42% and 23%, respectively.
Doses of ≤1.3×109 PFU were administered by hepatic infusion pump without dose-limiting toxicity or significant adverse events attributable to the virus [58].
We assessed that 5.7%% of the respiratory deaths were attributable to influenza virus during the 2009 2010 pandemic season.
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