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Roughly one third of all human cancers are attributable to the functional inhibition of the tumor suppressor protein p53 by its two negative regulators MDM2 and MDMX, making dual-specificity peptide antagonists of MDM2 and MDMX highly attractive drug candidates for anticancer therapy.
However, Raman spectra are inherently multiplexed in that a single spectrum typically contains multiple peaks attributable to the functional groups present in the sample.
Noticeably, this near-isoenergetic drug binding displayed by the QacR E57 and E58 mutants appears to be primarily attributable to the functional and chemical redundancy of residues that are capable of electrostatic neutralization in the QacR multidrug binding pocket.
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Although we observed 10-fold higher levels of IL-12 in the vhs- infections relative to KOS for cells isolated from mice deficient in TLR3, we suspect that the difference compared to infection of mu-cDCs from wild-type mice and MyD88 single knock-out mice (where TLR3 is present and functional) may be attributable to the function of vhs as a viral nuclease (see below).
This result is partly attributable to the extensive functional studies of genes in eukaryotic model organisms, especially in S. cerevisiae and S. pombe; a majority of Dikarya-core and Euk/Prok-core genes have homologs in S. pombe and/or S. cerevisiae.
Alternatively, the difference might be attributable to the morphological or functional differences between SOMs and PVs.
This is attributable to the multiligand functionality of RAGE.
These traits had in common that >50%% of trait variation was attributable to the summed effects of functional group, growth stature and species identity (Fig. 3).
The bands at 3385 3502 couldcould be attributable to the stretching of the hydroxyl functional group of catechol moiety.
Some aspects of item misfit are often attributable to the deviation from the assumed functional form of the item regression model, which are typically logistic or normal-ogive (probit) in form.
Moreover, a cognitively impenetrable process is assumed to be attributable solely to the functional architecture of the system, meaning that it can be considered primitive and non-representational. On the other hand, a process cannot be solely determined by the functional architecture of a system if changing ones beliefs or goals alters the process itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com