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Conclusion from Covance Laboratories Ltd. confirmed that the study did not identify any toxicity that was attributable to dosing with SMTC1100.
Of those admissions, 35% were due to adverse drug reactions, 24% were due to improper drug selection, and 26% were attributable to dosing errors.
An unplanned analysis of patients with full vs reduced dose of the combination therapy showed no differences in the clinical outcomes measured attributable to dosing differences.
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The lack of adverse association in the present study is not likely attributable to dose.
Although no dose reduction in paclitaxel dosing was required, a reduction in dose intensity was observed that was attributable to dose delay.
We estimate a 16% decline attributable to dose reductions, 10% to use of proton pump inhibitors, and 10% to use of less toxic NSAIDs.
The high proportion of patients that required at least one cetuximab dose reduction are attributable to dose adjustments planned in case of dose delay of chemotherapy due to haematological toxicity.
Our observation that the two concentrations of EtOH tested in vitro were able to elicit distinct changes in chromatin structure suggest some of the variation in FAS clinical cases may be attributable to dose-dependent alterations in the epigenetic program.
Women are affected by these reactions two times more often than men [ 33], a difference that may be attributable to dose-related toxicity that is more common among individuals with low body weight [ 34].
The extent to which bleeding risk is attributable to excess dosing of enoxaparin is unclear.
The reasons for the discrepancies between the present study and earlier work may be attributable to the dosing regimen, the different analogue utilized, the levels of GLP-1 achieved, and the timing of the treatment and the species studied [ 30].
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