Only one of the studies that employed multi-level analysis reported the proportion of variability attributable to each level of analysis [ 32].
Such studies have also rarely used multi-level analysis to account for clustering of outcomes by provider and to determine the proportion of variability attributable to each level of analysis (patient and provider)[ 31].
In the second step we used OPLS-DA to look for changes attributable to GM. Discrimination analysis using the metabolite profiles from the HC experiment indicated a high overall proximity between the transgenic lines and the control (Figure 4e).
To determine if overexpression of HER2 protein is attributable to gene amplification, FISH analysis was performed on samples scored 2+ and 3+ by HercepTest.
This method also has the advantage of allowing the proportion of variability attributable to each level of analysis to be determined [ 31].
As none of the published studies considered pre-alloHCT status, this discrepancy may be attributable to our risk factor analysis model adjusted for pre-alloHCT status.
Given differences in the experiments, we used Distance Weighted Discrimination (DWD) [ 17] to minimize systematic microarray data biases attributable to RNA source, different analysis laboratories, different microarrays, or other systematic differences which include sex and strain in this case.
The difference in our results may be attributable to our more detailed analysis based on a continuous outcome variable (SBP) rather than dichotomised data - the Danish study only identified success or failure in achieving a BP target.
Indeed, in a large matched cohort study of patients with early onset VAP [ 5], an association between VAP and poor clinical and economic outcomes was demonstrated, but hospital mortality was not attributable to VAP in this analysis.
14, 15 Although our findings of significant and substantial cost savings may appear to conflict with a recent economic analysis reporting increased costs attributable to parenteral nutrition, 19 this previously published economic analysis addressed a different clinical indication for parenteral nutrition than did our CMA.
This may be attributable to inadequate power of the analysis due to the small number of uveitis specialists (12) who responded to this survey.
