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But something in his laconic tone hints that the alternative — upending the table, perhaps — has been well considered and retains an attractive rationale.
In particular, this cascade is considered a molecular link between inflammation and cancer; therefore, targeting the cascade has become an attractive rationale in cancer therapy (Vallabhapurapu and Karin, 2009; DiDonato et al., 2012).
Thus, the hypothesis that AgRP might interfere in mechanisms independent of MC3R and MC4R constitutes an additional attractive rationale.
It has also been suggested that focal adhesions are the initiating site of mechanotransduction [ 332], offering an attractive rationale for topography-dependent cell response.
This unique mechanism of action provides an attractive rationale for future combination of Ang-(1 7) with other anti-angiogenic drugs.
These links have provided an attractive rationale for the over-expression of USP7 commonly seen in human cancers (reviewed in Hussain et al, 2009).
Similar(53)
Based on the GAR structure, we propose two attractive rationales for producing an efficient GR enzyme with NADH specificity.
These explorations provide attractive rationales for the potential to combine anti-angiogenic agents with immune treatment for cancer patients.
The top three motives for recruiting patients were: (1) the attractive scientific rationale of the trial (84%); (2) a design that was easy to explain to patients (79%); and (3) a pragmatic trial design in line with standard practice (76%).
This similarity and difference provide an attractive biological rationale for a quantitative functional comparison of homologous promoter and CRMs from mouse and fugu Msx1.
It's as if our military has concluded there's no attractive or saleable rationale for these wars that young American men and women will accept, will find worthy of risking their lives for.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com