The phrase "attenuation of protein" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly in discussions related to biochemistry, molecular biology, or pharmacology, where the reduction or weakening of protein function or concentration is being described.
Example: "The study focused on the attenuation of protein expression in response to the treatment."
Alternatives: "reduction of protein" or "diminution of protein".
In the present study, we observed the activation of adaptive responses, i.e., attenuation of protein synthesis, increased lipid biosynthesis, protein refolding and expression of anti-apoptotic protein Bcl2.
The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells.
The recently described detection of micro RNA (=miRNA, miR) introduced yet another complexity to the value of qRT-PCR namely post-transcriptional modification of translation in which mRNA level is stable with attenuation of protein synthesis.
One of the earliest responses is the attenuation of protein translation.
Activated PERK phosphorylates the translation initiation factor, eIF2α, resulting in a transient attenuation of protein translation.
Activation of the UPR results in transient attenuation of protein translation, enabling cells to cope with the existing protein load.
10.7554/eLife.03023.007 Figure 2. Attenuation of proteins encoded on duplicated chromosomes.
DOI: http://dx.doi.org/10.7554/eLife.03023.009 10.7554/eLiFigure2 figureigure 2—figure supplement 1. Attenuation of proteins encoded on duplicated chromosomes.
(C ) Attenuation of proteins encoded on duplicated chromosomes of meiotically generated aneuploid strains.
A subsequent quantitative proteomic study of five aneuploid yeasts obtained as progeny from triploid or pentaploid meioses found no evidence for the attenuation of proteins that form multi-subunit complexes (Pavelka et al., 2010).
The antioxidant function of eIF2 αP also involves the attenuation of general protein synthesis, which decreases client protein load and prevents illegitimate disulfide bond formation in the ER leading to a sufficient amount of reducing equivalents to alleviate cells from oxidative stress.
