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However, the visible attenuation of growth inhibition upon their depletion indicates a prominent role for these GTPases in resolving chlamydia infection – an observation consistent with a potentiating mode of function for hGBPs.
The mutant is also associated with early attenuation of growth in macrophages [ 134].
Attenuation of growth and increased cell death by drought or salt is attributed, in part, to ER stress [ 47, 48].
In addition, attenuation of growth is less evident for EGFP than EGFP-MVcf-expressing cells, although cells undergoing apoptotic death were not observed (Supplementary Figure S1-E).
Alternatively, the Grb2/FRS2α complex interacts with Cbl via the SH3 domains resulting in the ubiquitination of FGFRs and FRS2α for the attenuation of growth factor signaling [ 37].
Evidence based on cell-line experiments suggests that the attenuation of growth factor signaling is able to overcome endocrine therapy resistance [ 28].
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The smaller number of U-turns in the Stat3-ca/Y27632 and CNTF/Y27632 groups, as compared with the CNTF-treated nerves, is consistent with a local attenuation of growth-inhibitory cues by the blockade of ROCK.
It has been suggested that the stress-induced up-regulation of miR393 and miR160 might lead to the attenuation of plant growth and development under stress by repressing auxin signaling due to decreased TIR1 level and by suppressing the ARF-mediated gene expression, respectively, thus promoting plant stress tolerance [ 47].
PCA3-silenced LNCaP cells showed a significant attenuation of cell growth, with a corresponding increase in the number of cells undergoing apoptosis.
Its production is stimulated by growth hormone and can be inhibited by attenuation of the growth hormone response pathway.
Up-regulating FOXO4 inhibited the growth and metastasis of gastric cancer cell lines in vitro and led to dramatic attenuation of tumor growth, and liver and lung metastasis in vivo, whereas down-regulating FOXO4 with specific siRNAs promoted the growth and metastasis of gastric cancer cell lines.
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